Methyl isothiocyanate → Thiourea, N-(2,6-dichlorophenyl)-N'-methyl-

HRID 596650ノート

反応式

HRID 596650 の反応式
[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([Cl:9])[C:3]=1[NH2:4].[CH3:10][N:11]=[C:12]=[S:13]>C(O)C>[CH3:10][NH:11][C:12]([NH:4][C:3]1[C:2]([Cl:1])=[CH:8][CH:7]=[CH:6][C:5]=1[Cl:9])=[S:13]

参加物

4

反応物 2

HCID 11167Methyl isothiocyanateHCID 118462,6-Dichloroaniline

生成物 1

HCID 7942238Thiourea, N-(2,6-dichlorophenyl)-N'-methyl-

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

130 g of 2,6-dichloro-aniline, 100 g of methyl isothiocyanate and 300 ml of 95% ethanol are refluxed during 14 hours, with stirring. The resulting solution is cooled in the freezer: the white solid formed is filtered and washed with isopropyl oxide. After recrystallization from isopropanol, 65 g of product (III : R = CH3), m.p. = 184° C, are collected.

後処理

  1. temperatureThe resulting solution is cooled in the freezer
  2. customthe white solid formed
  3. filtrationis filtered
  4. washwashed with isopropyl oxide
  5. customAfter recrystallization from isopropanol, 65 g of product (III : R = CH3), m.p. = 184° C
  6. customare collected

出典と根拠

ORDレコード
ord-3971929cc6e24d77b53f34cdb3ed7ad5
出典データセット
uspto-grants-1977_03
特許番号
US04011342

反応ノート

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