Phosgene → HCID 53797236、化合物
反応式
[C:1](Cl)(Cl)=[O:2].[Cl:5][CH:6]1[CH2:11][CH2:10][CH:9]([C:12]2[S:16][C:15]([NH2:17])=[N:14][N:13]=2)[CH2:8][CH2:7]1>C(OCC)(=O)C>[Cl:5][CH:6]1[CH2:7][CH2:8][CH:9]([C:12]2[S:16][C:15]([N:17]=[C:1]=[O:2])=[N:14][N:13]=2)[CH2:10][CH2:11]1参加物
4
実験手順
A saturated solution of phosgene in ethyl acetate (500 ml) is charged into a glass reaction vessel equipped with a mechanical stirrer. 5-(4-Chlorocyclohexyl)-2-amino-1,3,4-thiadiazole (6 grams) is added to the reaction vessel and the resulting mixture is stirred and heated at reflux for a period of about 4 hours, resulting in the formation of a precipitate. The reaction mixture is then purged with nitrogen gas to remove unreacted phosgene. The purged mixture is then filtered to recover the precipitate. The precipitate is then recrystallized to yield the desired product 5-(4-chlorocyclohexyl)-1,3,4-thiadiazol-2-yl isocyanate dimer.