N-(2-Hydroxyethyl)-4-nitrophthalimide → 5-Amino-2-(2-hydroxy-ethyl)-isoindole-1,3-dione
反応式
[OH:1][CH2:2][CH2:3][N:4]1[C:8](=[O:9])[C:7]2=[CH:10][C:11]([N+:14]([O-])=O)=[CH:12][CH:13]=[C:6]2[C:5]1=[O:17].[H][H]>[Ni].C(O)C>[NH2:14][C:11]1[CH:10]=[C:7]2[C:8](=[O:9])[N:4]([CH2:3][CH2:2][OH:1])[C:5](=[O:17])[C:6]2=[CH:13][CH:12]=1参加物
5
実験手順
N-(2-Hydroxyethyl)-4-nitrophthalimide (30.0 g.), ethanol (300 ml.), and Raney nickel (3.0 g.) are mixed and hydrogenated at 100° C. and 1500 psi. until hydrogen uptake ceases. The hot solution is filtered to remove the Raney nickel and the solvent evaporated to yield 4-amino-N-(2-hydroxyethyl)-phthalimide, the amine which melts at 171°-173° C.
後処理
- filtrationThe hot solution is filtered
- customto remove the Raney nickel
- customthe solvent evaporated
出典と根拠
- ORDレコード
- ord-fcf0a85fd0404e8fae621773a21e2910
- 出典データセット
- uspto-grants-1977_03
- 特許番号
- US04012372
反応ノート
読み込み中…