4-nitro-N-ethylphthalimide → 5-Amino-2-ethylisoindoline-1,3-dione
反応式
[CH2:1]([N:3]1[C:7](=[O:8])[C:6]2=[CH:9][C:10]([N+:13]([O-])=O)=[CH:11][CH:12]=[C:5]2[C:4]1=[O:16])[CH3:2]>[Ni].C(O)C>[NH2:13][C:10]1[CH:9]=[C:6]2[C:7](=[O:8])[N:3]([CH2:1][CH3:2])[C:4](=[O:16])[C:5]2=[CH:12][CH:11]=1参加物
4
実験手順
N-Ethyl-4-nitrophthalimide (28.0 g.) is hydrogenated in 400 ml. of ethanol and in the presence of Raney nickel catalyst (10 g.) at 100° C. and 1500 psi. pressure. The reaction mixture is filtered to remove the catalyst and the filtrate is concentrated to yield the product, 4-amino-N-ethylphthalimide, which is recrystallized from methanol-water mixture. It melts at 169°-171° C.
後処理
- customat 100° C.
- filtrationThe reaction mixture is filtered
- customto remove the catalyst
- concentrationthe filtrate is concentrated
出典と根拠
- ORDレコード
- ord-823e199231b84fccb6100f6f7eb897a2
- 出典データセット
- uspto-grants-1977_03
- 特許番号
- US04012372
反応ノート
読み込み中…