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Phosphorus oxychloride → 3-Chlorocinnamonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | Sodium Pyrosulfite | HCID 656671 | — |
| 反応物 | 3-(3-Chlorophenyl)prop-2-enamide | HCID 53439624 | — |
| 生成物 | 3-Chlorocinnamonitrile | HCID 367316 | 59.5% |
反応手順
m-Chlorocinnamamide (1.39 g.) was mixed with sodium metabisulphite (0.72 g.) and phosphoryl chloride (3 ml.). The mixture was heated on the steam-bath for 2.5 hr. and the phosphoryl chloride removed under reduced pressure. The residue was washed well with water, leaving slightly impure m-chlorocinnamonitrile (0.744 g., 59.5%). Recrystallisation from aqueous acetone gave m-chlorocinnamonitrile, m.p. 56°-57°, λmax. (EtOH) 226, 270 nm. ε 19000, 22500.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04012377 |
| 出典データセット | uspto-grants-1977_03 |
| ORD ID | ord-f89108d6e9ad4052b1035597098795e2 |
| 出典メモ | uspto-grants-1977_03 |