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N-t-butoxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-D-alanine amide → N-benzyloxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-t-butoxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-D-alanine amide | HCID 22796331 | — |
| 反応物 | L-methionyl-L-aspartyl-D-alanine amide hydrochloride | HCID 22796354 | — |
| 反応物 | L-methionyl-L-aspartyl-DL-norvaline amide hydrochloride | HCID 22796370 | — |
| 反応物 | (S)-2,4,5-Trichlorophenyl 2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoate | HCID 54123710 | — |
| 生成物 | N-benzyloxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide | HCID 22796407 | — |
反応手順
When equivalent quantities of L-methionyl-L-aspartyl-DL-norvaline amide hydrochloride and N-benzyloxycarbonyl-L-tryptophan 2,4,5-trichlorophenyl ester are substituted for the L-methionyl-L-aspartyl-D-alanine amide hydrochloride and the N-t-butoxycarbonyl-L-tryptophan 2,4,5-trichlorophenyl ester of Example 6, and the procedure detailed therein substantially repeated, there is obtained N-benzyloxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide. This compound is represented by the following formula.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04012367 |
| 出典データセット | uspto-grants-1977_03 |
| ORD ID | ord-62f041f3e12a42e387075b636bb87788 |
| 出典メモ | uspto-grants-1977_03 |