化工社化工社 化学情報印刷レポート · 研究参考用
Hydrogen Bromide → L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide hydrobromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | N-benzyloxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide | HCID 22796407 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Ethyl methyl sulfide | HCID 12230 | — |
| 生成物 | L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide hydrobromide | HCID 22796390 | — |
反応手順
N-benzyloxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide is dissolved in 10 parts glacial acetic acid containing 2 parts methylethyl sulfide. Then, 10 parts of 6 M hydrobromic acid in acetic acid is added and the solution is allowed to stand for one hour at room temperature. The solvents are removed under vacuum below 40° C. and the residue shaken with ether to afford L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide hydrobromide. This compound is represented by the following formula.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04012367 |
| 出典データセット | uspto-grants-1977_03 |
| ORD ID | ord-8ac2eeb5e3e447358b5e3ac14dbce5f5 |
| 出典メモ | uspto-grants-1977_03 |