Triethylamine → HCID 21448606、化合物

HRID 596871ノート

反応式

HRID 596871 の反応式
Cl[C:2]([C:4]([CH2:11][CH3:12])([CH2:9][CH3:10])[C:5]([O:7][CH3:8])=[O:6])=[O:3].C(N(CC)CC)C.[CH3:20][O:21][C:22](=[O:27])[CH2:23][CH2:24][NH:25][CH3:26]>CCOCC>[CH2:9]([C:4]([CH2:11][CH3:12])([C:2](=[O:3])[N:25]([CH3:26])[CH2:24][CH2:23][C:22]([O:21][CH3:20])=[O:27])[C:5]([O:7][CH3:8])=[O:6])[CH3:10]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 12414198Methyl N-methyl-beta-alaninateHCID 21448656HCID 21448656、化合物

生成物 1

HCID 21448606HCID 21448606、化合物収率 93%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

反応条件

温度
-10 °C

実験手順

To a solution of 19.2 g of methyl 2-chloroformyl-2-ethyl-butyrate and 20 g of triethylamine in 100 ml of dry ether, which is mechanically stirred and cooled at -10° C, there is added dropwise 12.8 g of N-methyl-β-alanine methyl ester dissolved in 50 ml of dry ether. After the addition, which takes 30 minutes, the mixture is stirred during 18 hours at room temperature. After filtration of the separated triethylamine hydrochloride, the solvent is evaporated leaving the desired product as an oil, boiling at 118° C (0.2 mm). Yield 93%. nD19 1.4646.

後処理

  1. additionAfter the addition, which
  2. filtrationAfter filtration of the separated triethylamine hydrochloride
  3. customthe solvent is evaporated

出典と根拠

ORDレコード
ord-9b25783c665246b386d839daaff9011c
出典データセット
uspto-grants-1977_03
特許番号
US04012392

反応ノート

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