Sulfuric Acid → (5,6-Diethyl-3-oxo-2-benzofuran-1(3H)-ylidene)acetonitrile

HRID 596897ノート

反応式

HRID 596897 の反応式
[N:1]([C:4]1[C:5](=[O:19])[C:6]2[C:11]([C:12](=[O:14])[CH:13]=1)=[CH:10][C:9]([CH2:15][CH3:16])=[C:8]([CH2:17][CH3:18])[CH:7]=2)=[N+]=[N-].S(=O)(=O)(O)O>>[C:4]([CH:13]=[C:12]1[C:11]2[C:6](=[CH:7][C:8]([CH2:17][CH3:18])=[C:9]([CH2:15][CH3:16])[CH:10]=2)[C:5](=[O:19])[O:14]1)#[N:1]

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 123664032-Azido-6,7-diethylnaphthalene-1,4-dione

生成物 1

HCID 54399111(5,6-Diethyl-3-oxo-2-benzofuran-1(3H)-ylidene)acetonitrile収率 91.7%

実験手順

2-Azido-6,7-diethyl-1,4-naphthoquinone (6.0 g; 0.024 mole) was added portionwise to cold (0°-5° C), stirred concentrated sulphuric acid (100 ml) over 2 hours and the red solution stirred at this temperature till no further nitrogen evolution was noticed (ca. 15 mins.). The products from two such reactions carried out simultaneously were poured into 1200 ml of ice-water and the lilac solid filtered off and washed well with water. Recrystallisation from ethanol in the presence of charcoal give the title compound 5.00 g (47%) as an off-white solid of m.p. 147°-158° C. Further recrystallisation gave a white sample of m.p. 159°-168° C. shown by nmr to be a mixture of E and Z isomers. (Found; C, 73.70; H, 5.95; N, 5.94; C14H13NO2 requires; C, 73.99; H, 5.77; N, 6.16%).

後処理

  1. custom(ca. 15 mins.)
  2. filtrationthe lilac solid filtered off
  3. washwashed well with water
  4. customRecrystallisation from ethanol in the presence of charcoal

出典と根拠

ORDレコード
ord-d54a4239e8f7490eb681f436291f6c08
出典データセット
uspto-grants-1977_03
特許番号
US04012407

反応ノート

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