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Hydrazine hydrate (1:1) → 7-Chloro-2-hydrazinyl-5-phenyl-3H-1,4-benzodiazepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | Thionordiazepam | HCID 826706 | — |
| 生成物 | 7-Chloro-2-hydrazinyl-5-phenyl-3H-1,4-benzodiazepine | HCID 12390874 | — |
反応手順
A mixture of 7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione and hydrazine hydrate is allowed to stand for 72 hours at about 25° C. After evaporation of the ethanol, the solid products obtained are recrystallized from methylene chloride-benzene to give 7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine of melting point 204°-207° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04012413 |
| 出典データセット | uspto-grants-1977_03 |
| ORD ID | ord-5427413b7754496a8b7156cf9e16122d |
| 出典メモ | uspto-grants-1977_03 |