Formamide → 6-Hydroxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde
反応式
Br.[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH2:6]2.[CH:13](N)=[O:14]>O>[CH:13]([N:8]1[CH2:7][CH2:6][C:5]2[C:10](=[CH:11][CH:12]=[C:3]([OH:2])[CH:4]=2)[CH2:9]1)=[O:14]参加物
4
反応条件
- 温度
- 100 °C
実験手順
46.0 g of 1,2,3,4-tetrahydro-6-hydroxy-isoquinoline-hydrobromide are reacted with 85 ml of formamide for 1 hour at 140° C. with stirring. After cooling to 100° C., 216 ml of water are added, whereby the reaction product crystallizes. 34.0 g of 2-formyl-1,2,3,4-tetrahydro-6-hydroxy-isoquinoline are obtained. m.p. = 185.5° - 186° C. (ethanol).
後処理
- customwhereby the reaction product crystallizes
出典と根拠
- ORDレコード
- ord-3aa79ced6f8a404c8534bcfc361a94b0
- 出典データセット
- uspto-grants-1977_03
- 特許番号
- US04013663
反応ノート
読み込み中…