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3-Chloropropionitrile → 3-(3-Trifluoromethylphenylthio)-propionitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Chloropropionitrile | HCID 10963 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 3-(Trifluoromethyl)benzenethiol | HCID 136751 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-(3-Trifluoromethylphenylthio)-propionitrile | HCID 19843936 | — |
反応手順
A solution of 15.9 g (0.09 mol) of 3-trifluoromethylthiophenol and 3.8 g (0.095 mol) of sodium hydroxide pellets in 100 ml of water is heated at 65°-70° C and 8.5 g (0.095 mol) of β-chloropropionitrile are added dropwise whilst stirring. The mixture is heated for a quarter of an hour to the reflux temperature and is then cooled and extracted with ether, and the extract is washed with water and dried with magnesium sulphate. This gives 3-(3-trifluoromethylphenylthio)-propionitrile, which is not isolated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04013776 |
| 出典データセット | uspto-grants-1977_03 |
| ORD ID | ord-56a53ea130574dc8acfa973d562739c3 |
| 出典メモ | uspto-grants-1977_03 |