3-Pentanamine → HCID 21445076、化合物

HRID 597463ノート

反応式

HRID 597463 の反応式
[CH2:1]([C:5]1[N:10]=[C:9](Cl)[C:8]([N+:12]([O-:14])=[O:13])=[C:7]([Cl:15])[N:6]=1)[CH2:2][CH2:3][CH3:4].[NH2:16][CH:17]([CH2:20][CH3:21])[CH2:18][CH3:19]>C(N(CC)CC)C>[CH2:1]([C:5]1[N:6]=[C:7]([Cl:15])[C:8]([N+:12]([O-:14])=[O:13])=[C:9]([NH:16][CH:17]([CH2:20][CH3:21])[CH2:18][CH3:19])[N:10]=1)[CH2:2][CH2:3][CH3:4]

参加物

4

反応物 2

HCID 120193-PentanamineHCID 12280647Pyrimidine, 2-butyl-4,6-dichloro-5-nitro-

生成物 1

HCID 21445076HCID 21445076、化合物

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

200 ml of alcohol and 4.5 g (44 m-moles) of triethylamine are added to 11 g (44 m-moles) of 2-n-butyl-4,6-dichloro-5-nitro-pyrimidine. At -50° C, 4.0 g (44 m-moles of 3-aminopentane are added dropwise. The reaction mixture is stirred for 3 hours and then evaporated. The residue is suspended in 100 ml of water and extraction is performed with ether. The ethereal extracts are dried over MgSO4 and evaporated to yield 10.5 g of 2-n-butyl-4-chloro-5-nitro-6-(3-pentylamino)-pyrimidine (nD20 : 1.5383) as a yellow oil

後処理

  1. customevaporated
  2. extractionextraction
  3. dry with materialThe ethereal extracts are dried over MgSO4
  4. customevaporated

出典と根拠

ORDレコード
ord-c56881d8bbf0483d8bf3f8acd467bb9e
出典データセット
uspto-grants-1977_03
特許番号
US04014677

反応ノート

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