Hydrochloric Acid → 1-(3'-Formylamino-phenyl)-2-amino-propane hydrochloride
反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH2:8][CH:9]([NH2:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1.[ClH:12].[CH3:13][OH:14]>>[ClH:12].[CH:13]([NH:1][C:2]1[CH:3]=[C:4]([CH2:8][CH:9]([NH2:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1)=[O:14]参加物
4
実験手順
255 gm of 1-(3'-amino-phenyl)-2-amino-propane were dissolved in methanol, and the solution was acidified with ethereal hydrochloric acid. The monohydrochloride thus obtained was refluxed for 2 hours in 225 ml of formic acid, and the reaction mixture was then evaporated in a water aspirator vacuum, leaving a yellow oil which solidified upon being digested with ether. The solidified product was recrystallized from ethanol by addition of ether, yielding the compound of the formula ##STR15## which had a melting point of 150°-153° C.
出典と根拠
- ORDレコード
- ord-e8d47a72ce1847918b8c9754d0c6f5c5
- 出典データセット
- uspto-grants-1977_03
- 特許番号
- US04015011
反応ノート
読み込み中…