Ethyl formate → HCID 21327419、化合物

HRID 597728ノート

反応式

HRID 597728 の反応式
[NH:1]([C:5]1[CH:6]=[C:7]([CH2:11][CH:12]([NH2:14])[CH3:13])[CH:8]=[CH:9][CH:10]=1)[C:2]([NH2:4])=[O:3].[CH:15](OCC)=[O:16]>>[NH:1]([C:5]1[CH:6]=[C:7]([CH2:11][CH:12]([NH:14][CH:15]=[O:16])[CH3:13])[CH:8]=[CH:9][CH:10]=1)[C:2]([NH2:4])=[O:3]

参加物

3

反応物 2

HCID 8025Ethyl formateHCID 21327414N-[3-(2-Aminopropyl)phenyl]urea

生成物 1

HCID 21327419HCID 21327419、化合物

実験手順

A mixture consisting of 4.8 gm of 1-(3'-ureido-phenyl)-2-amino-propane and 5 ml of ethyl formate was refluxed for 5 hours. Thereafter, the reaction solution was evaporated, and the residue was purified by chromatography on a silicagel column, using methanol/chloroform (2:8) as the flow agent. The eluate was evaporated, and the residue was recrystallized from ethanol and ether, yielding the compound of the formula ##STR25## which had a melting point of 133-136° C.

後処理

  1. temperaturewas refluxed for 5 hours
  2. customThereafter, the reaction solution was evaporated
  3. customthe residue was purified by chromatography on a silicagel column
  4. customThe eluate was evaporated
  5. customthe residue was recrystallized from ethanol and ether
  6. customyielding the compound of the formula ##STR25## which

出典と根拠

ORDレコード
ord-4ba4e039d88d4cf4a235a676c5c0bea4
出典データセット
uspto-grants-1977_03
特許番号
US04015011

反応ノート

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