1-(3'-Nitro-phenyl)-2-formylamino-propane → 1-(3'-Aminophenyl)-2-formylamino-propane

HRID 597733ノート

反応式

HRID 597733 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][CH:11]([NH:13][CH:14]=[O:15])[CH3:12])[CH:7]=[CH:8][CH:9]=1)([O-])=O>CO.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]([CH2:10][CH:11]([NH:13][CH:14]=[O:15])[CH3:12])[CH:7]=[CH:8][CH:9]=1

参加物

4

反応物 1

HCID 213274321-(3'-Nitro-phenyl)-2-formylamino-propane

生成物 1

HCID 213274251-(3'-Aminophenyl)-2-formylamino-propane

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

5.2 gm of 1-(3'-nitro-phenyl)-2-formylamino-propane was hydrogenated in methanol in the presence of Raney nickel at atmospheric pressure and room temperature. Thereafter, the catalyst was filtered off, the solvent was evaporated from the filtrate, and the residue was chromatographed on a silicagel column, using methanol/chloroform (2:8) as the flow agent. The eluate was evaporated, and the residue was recrystallized from ethyl acetate, yielding 1-(3'-aminophenyl)-2-formylamino-propane which had a melting point of 107° -108° C.

後処理

  1. filtrationThereafter, the catalyst was filtered off
  2. customthe solvent was evaporated from the filtrate
  3. customthe residue was chromatographed on a silicagel column
  4. customThe eluate was evaporated
  5. customthe residue was recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-a17087da65784c37a316599519ad01b6
出典データセット
uspto-grants-1977_03
特許番号
US04015011

反応ノート

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