関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | t-Butyl bromide | HCID 10485 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Pentynoic acid | HCID 22464 | — |
| 触媒 | Benzyl triethylammonium chloride | HCID 66133 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | 4-Pentynoic acid, 1,1-dimethylethyl ester | HCID 10877341 | — |
反応手順
Benzyltriethylammonium chloride (5.92 g), potassium carbonate (93.4 g), and t-butyl bromide (143 ml) were added to a solution of 4-pentynoic acid (2550 mg) in N,N-dimethylacetamide (230 ml), and this reaction mixture was stirred at 55° C. for 24 hours. After water was added, the reaction mixture was extracted with ethyl acetate, washed with water, dried over anhydrous magnesium chloride, and then filtered through silica gel. The filtrate was concentrated under reduced pressure to give the title compound (2.10 g). This compound was used in the following reaction without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07897387B2 |
|---|
| 出典データセット | uspto-grants-2011_03 |
|---|
| ORD ID | ord-c8b59da672be474998bc6fc2c9998c2d |
|---|
| 出典メモ | uspto-grants-2011_03 |
|---|
