Ethanol → HCID 46914009、化合物

HRID 597845ノート

反応式

HRID 597845 の反応式
[C:1]([CH2:4][CH2:5][C:6]1[C:14]2[C:13](=[O:15])[CH2:12][CH2:11][CH2:10][C:9]=2[NH:8][CH:7]=1)([OH:3])=[O:2].S(=O)(=O)(O)O.[CH2:21](O)[CH3:22]>>[CH2:21]([O:2][C:1](=[O:3])[CH2:4][CH2:5][C:6]1[C:14]2[C:13](=[O:15])[CH2:12][CH2:11][CH2:10][C:9]=2[NH:8][CH:7]=1)[CH3:22]

参加物

4

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 158327213-(4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoic acid

生成物 1

HCID 46914009HCID 46914009、化合物収率 99%

実験手順

3-Carboxyethyl-4-oxo-4,5,6,7-tetrahydro-1H-indole (3, 52.0 g, 0.251 mol) in ethanol (100 mL) was added with sulfuric acid (1.0 mL). The reaction mixture was heated at reflux for 12 h. The solution was concentrated under reduced pressure and the resultant solids were washed with water (200 mL×2). The solids were air-dried to give 3-(3-ethoxy-3-oxopropyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole (4, 59.0 g, 0.251 mol) as yellow solids in >99% yield.

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 12 h
  3. concentrationThe solution was concentrated under reduced pressure
  4. washthe resultant solids were washed with water (200 mL×2)
  5. customThe solids were air-dried

出典と根拠

ORDレコード
ord-c2e866c8818e4e0d91f3499cf7eebf1d
出典データセット
uspto-grants-2011_03
特許番号
US07897602B2

反応ノート

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