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Potassium Carbonate → HCID 178509280、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | N-(2-((4-chlorophenethyl)(piperidin-4-yl)amino)ethyl)benzamide | HCID 121410331 | — |
| 反応物 | N-cyanopiperazine-1-carbimidothioate | HCID 131737066 | — |
| 生成物 | HCID 178509280 | HCID 178509280 | — |
反応手順
N-(2-((4-Chlorophenethyl)(piperidin-4-yl)amino)ethyl)benzamide obtained in Step 4 was reacted with K2CO3 and S,S′-dimethyl-N-cyano-dithioiminocarbonate, followed by the cyclization of the intermediate (N-cyanopiperazine-1-carbimidothioate) with hydrazine monohydrate in a manner described in Procedure 3. Purification over silica gel provided pure product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09440953B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-74267245d16542a2bcfaf4369e448bf8 |
| 出典メモ | uspto-grants-2016_09 |