Benzylamine → N-Benzyl-5-hydroxycyclohex-3-enecarboxamide
反応式
[CH:1]12[CH2:9][CH:5]([O:6][C:7]1=[O:8])[CH:4]=[CH:3][CH2:2]2.[CH2:10]([NH2:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[CH2:10]([NH:17][C:7]([CH:1]1[CH2:9][CH:5]([OH:6])[CH:4]=[CH:3][CH2:2]1)=[O:8])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1参加物
3
実験手順
To 6-oxabicyclo[3.2.1]oct-3-en-7-one (2.6 g, 21 mmol) in xylenes (50 ml) under nitrogen was added benzylamine (3.42 g, 32 mmol). The mixture was heated under reflux for 16 h, then cooled to room temperature. The heavy white precipitate was collected by filtration, and recrystallized from dichloromethane/hexane to give the amide as a white solid (3.8 g, 78%, m.p. 127-128° C.).
後処理
- temperatureThe mixture was heated
- temperatureunder reflux for 16 h
- filtrationThe heavy white precipitate was collected by filtration
- customrecrystallized from dichloromethane/hexane
出典と根拠
- ORDレコード
- ord-c75270c713304e6cb394d804eee0ba21
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07897611B2
反応ノート
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