Ammonia → 3-Azabicyclo[3.2.1]octan-6-one ethylene ketal
反応式
CS(O[CH2:6][CH:7]1[CH2:15][CH:14]([CH2:16]OS(C)(=O)=O)[CH2:13][C:8]21[O:12][CH2:11][CH2:10][O:9]2)(=O)=O.[NH3:22]>>[CH2:11]1[O:12][C:8]2([CH2:13][CH:14]3[CH2:15][CH:7]2[CH2:6][NH:22][CH2:16]3)[O:9][CH2:10]1参加物
3
反応条件
- 温度
- 60 °C
実験手順
6,8-Bis(methanesulfonyloxymethyl)-1,4-dioxaspiro[4.4]nonane (14.90 g, 43.3 mmol) was suspended in aqueous ammonia (35%, 150 ml) and heated for 18 h at 60° C. The reaction was cooled to ambient temperature and concentrated by rotary evaporation. The residue was treated with saturated sodium chloride solution (50 ml) and extracted with chloroform (3×50 ml). The organic extracts were combined, dried over sodium sulfate, filtered and concentrated to yield a brown oil (7.69 g, 100%).
後処理
- temperatureThe reaction was cooled to ambient temperature
- concentrationconcentrated by rotary evaporation
- additionThe residue was treated with saturated sodium chloride solution (50 ml)
- extractionextracted with chloroform (3×50 ml)
- dry with materialdried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-044189f66c8d4f468dedd5b8ce705a2e
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07897611B2
反応ノート
読み込み中…