Chloroacetaldehyde → 2-Amino-7-methyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
反応式
[NH2:1][C:2]1[N:7]=[C:6](O)[CH:5]=[C:4]([NH:9][CH3:10])[N:3]=1.Cl[CH2:12]C=O.[C:15](=[O:18])([O-])[O-].[K+].[K+]>CO>[NH2:1][C:2]1[NH:7][C:15](=[O:18])[C:5]2[CH:6]=[CH:12][N:9]([CH3:10])[C:4]=2[N:3]=1参加物
5
実験手順
To a suspension of 2-amino-6-(methylamino)pyrimidin-4-ol (40.5 g, 289 mmol) in methanol (300 ml) was added 40% aqueous chloroacetoaldehyde (51.6 ml, 318 mmol) and potassium carbonate (44.0 g, 318 mmol), and the mixture was refluxed for 1 hour. After cooling, the resulting crystals were collected by filtration and washed with water to give 19.4 g (41%) of the title compound.
後処理
- temperaturethe mixture was refluxed for 1 hour
- temperatureAfter cooling
- filtrationthe resulting crystals were collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-b4cb5bd383654b8a8e20191683830e5e
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07897607B2
反応ノート
読み込み中…