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Acetic Acid → HCID 178418605、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 反応物 | HCID 178418619 | HCID 178418619 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Methanol--water (1/1) | HCID 22242641 | — |
| 生成物 | HCID 178418605 | HCID 178418605 | 67.6% |
反応手順
(+-)-(Z)-Ethyl-6-[[2-phenyl-3-(1H-imidazol-1-yl)-2,3-dihydro-4H-benzopyranylidene]aminoxy]hexanoate (300 mg; 0.67 mmoles) is dissolved in methanol-water (5:2; 7 ml), and to this solution sodium methylate (90 mg; 1.61 mmoles) is added portion-wise at 0° C. The resulting solution is stirred at r.t. for 28 hrs., then diluted with water, cooled at 0° C. and neutralized with acetic acid. The so formed precipitate is collected and recrystallized from ethyl acetate to give a white solid (190 mg), melting at 176°-178° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05246956 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-c80aa69c1d3242f49b34a59f1fc7f324 |
| 出典メモ | uspto-grants-1993_09 |