Benzeneacetonitrile, 4-methoxy- → 3-(4-Methoxy-phenyl)-5-(2-p-tolyl-2H-pyrazol-3-yl)-benzo[c]isoxazole

HRID 59835

反応式

HRID 59835 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:14]([C:15]3[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=3)[N:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)([O-])=[O:2].[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30]C#N)=[CH:26][CH:25]=1>>[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]2[O:2][N:1]=[C:4]3[CH:9]=[CH:8][C:7]([C:10]4[N:14]([C:15]5[CH:16]=[CH:17][C:18]([CH3:21])=[CH:19][CH:20]=5)[N:13]=[CH:12][CH:11]=4)=[CH:6][C:5]=23)=[CH:26][CH:25]=1

参加物

3

反応物 2

HCID 66031Benzeneacetonitrile, 4-methoxy-HCID 900328535-(4-nitro-phenyl)-1 p-tolyl-1H-pyrazole2 回

生成物 1

HCID 730531493-(4-Methoxy-phenyl)-5-(2-p-tolyl-2H-pyrazol-3-yl)-benzo[c]isoxazole

実験手順

The title compound, light brown solid (17 mg, 12%), MS (ISP) m/z=382.4 [(M+H)+], mp 165° C., was prepared in accordance with the general method of example 1 from 5-(4-nitro-phenyl)-1-p-tolyl-1H-pyrazole (intermediate E) (100 mg, 353 μmol) and commercially available 2-(4-methoxy-phenyl)-acetonitrile.

出典と根拠

ORDレコード
ord-a12ed7e68b134b90b9e31b3e27508873
出典データセット
uspto-grants-2016_09
特許番号
US09440962B2

関連ノート

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