Water → HCID 57438270、化合物

HRID 598404ノート

反応式

HRID 598404 の反応式
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][NH:5][C:4](=[O:11])[CH:3]=1.[F:12][C:13]1[CH:19]=[C:18]([I:20])[CH:17]=[CH:16][C:14]=1[NH2:15].O>CCO.Cl>[F:12][C:13]1[CH:19]=[C:18]([I:20])[CH:17]=[CH:16][C:14]=1[NH:15][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][NH:5][C:4](=[O:11])[CH:3]=1

参加物

6

反応物 3

HCID 962WaterHCID 1856942-Fluoro-4-iodoanilineHCID 426090674-Chloro-5-nitropyridin-2(1H)-one

生成物 1

HCID 57438270HCID 57438270、化合物収率 45%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid触媒HCID 702Ethanol溶媒

反応条件

温度
90 °C

実験手順

To the mixture of 4-chloro-5-nitropyridin-2(1H)-one (90.1 mg, 0.517 mmol) and 2-fluoro-4-iodoaniline (137.5 mg, 0.58 mmol) dissolved in EtOH (5 mL) was added 6 drops of HCl (37% wt in water). The reaction vessel was closed and heated at 90° C. for 48 hours. After cooling to room temperature, water was added, and the solution was stirred at room temperature for 20 min. The precipitate was filtered, washed with water, dried under vacuum and used for the next reaction without further purification. (87.3 mg, 45% yield).

後処理

  1. customThe reaction vessel was closed
  2. temperatureAfter cooling to room temperature
  3. filtrationThe precipitate was filtered
  4. washwashed with water
  5. customdried under vacuum
  6. customused for the next reaction without further purification

出典と根拠

ORDレコード
ord-62f399ff62994252ba8f20e2dd55170b
出典データセット
uspto-grants-2011_03
特許番号
US07897624B2

反応ノート

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