Benzeneacetonitrile, 3-fluoro- → 5-[2-(2,4-Difluoro-phenyl)-2H-pyrazol-3-yl]-3-(3-fluoro-phenyl)-benzo[c]isoxazole

HRID 59845

反応式

HRID 59845 の反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:13]([C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=O)=[CH:16][CH:15]=2)=[CH:12][CH:11]=[N:10]1.[F:23][C:24]1[CH:25]=[C:26]([CH2:30]C#N)[CH:27]=[CH:28][CH:29]=1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:13]([C:14]2[CH:19]=[CH:18][C:17]3=[N:20][O:22][C:30]([C:26]4[CH:27]=[CH:28][CH:29]=[C:24]([F:23])[CH:25]=4)=[C:16]3[CH:15]=2)=[CH:12][CH:11]=[N:10]1

参加物

3

反応物 2

HCID 68145Benzeneacetonitrile, 3-fluoro-HCID 900332241-(2,4-difluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole2 回

生成物 1

HCID 730532965-[2-(2,4-Difluoro-phenyl)-2H-pyrazol-3-yl]-3-(3-fluoro-phenyl)-benzo[c]isoxazole

実験手順

The title compound, light yellow solid (85 mg, 65%), MS (ISP) m/z=392.2 [(M+H)+], mp 165° C., was prepared in accordance with the general method of example 1 from 1-(2,4-difluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole (intermediate I) (100 mg, 353 μmol) and commercially available 2-(3-fluoro-phenyl)-acetonitrile.

出典と根拠

ORDレコード
ord-f42fe945cc5d4225871be20837cb4799
出典データセット
uspto-grants-2016_09
特許番号
US09440962B2

関連ノート

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