4'-Hydroxyacetophenone → 4-(4-Acetylphenoxy)-5-nitropyridine

反応式

[CH3:1][C:2]([C:4]1[CH:5]=[CH:6][C:7]([OH:10])=[CH:8][CH:9]=1)=[O:3].Cl[C:12]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][N:13]=1>>[C:2]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:16]2[C:15]([N+:18]([O-:20])=[O:19])=[CH:14][N:13]=[CH:12][CH:17]=2)=[CH:6][CH:5]=1)(=[O:3])[CH3:1]

参加物

反応物 2

HCID 74694'-Hydroxyacetophenone

HCID 783082-Chloro-5-nitropyridine

生成物 1

HCID 231372284-(4-Acetylphenoxy)-5-nitropyridine

実験手順

Entry 9: 4-Hydroxyacetophenone was reacted with 2-chloro-5-nitropyridine to give 4-(4-acetylphenoxy)-5-nitropyridine according to Method A3, Step 2. According to Method A8, Step 4,4-(4-acetylphenoxy)-5-nitropyridine was reduced to 4-(4-acetylphenoxy)-5-aminopyridine. 2-Methoxy-5-(trifluoromethyl)aniline was converted to 2-methoxy-5-(trifluoromethyl)phenyl isocyanate according to Method B1. The isocyanate was reacted with 4-(4-acetylphenoxy)-5-aminopyridine according to Method C1a to afford the urea.

出典と根拠

ORDレコード: ord-45d566bb3bbb47988fa08f72df608446
出典データセット: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07897623B2

反応ノート

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