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Tetrahydrofurfurylamine → 3-(4-Nitrophenoxy)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofurfurylamine | HCID 253298 | — |
| 反応物 | 3-(4-Nitrophenoxy)benzoic acid | HCID 767919 | — |
| 生成物 | 3-(4-Nitrophenoxy)benzoic acid | HCID 767919 | — |
| 生成物 | 3-(4-nitrophenoxy)-N-(tetrahydro-2-furanylmethyl)benzamide | HCID 2986507 | — |
反応手順
Entry 63: 4-(3-Carboxyphenoxy)-1-nitrobenzene was synthesized according to Method A13, Step 2. 4-(3-Carboxyphenoxy)-1-nitrobenzene was coupled with tetrahydrofurfurylamine according to Method A13, Step 3 to give 4-(3-(N-(tetrahydrofurylmethyl)carbamoyl)phenoxy)-1-nitrobenzene. According to Method A13 Step 4,4-(3-(N-(tetrahydrofurylmethyl)carbamoyl)phenoxy)-1-nitrobenzene was reduced to 4-(3-(N-(tetrahydrofurylmethyl)carbamoyl)phenoxy)aniline. According to Method C1a, 4-chloro-3-(trifluoromethyl)phenyl isocyanate was reacted with 4-(3-(N-(tetrahydrofurylmethyl)carbamoyl)phenoxy)aniline to afford the urea.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07897623B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-890a2e5efa874de1806c6774360eb94b |
| 出典メモ | uspto-grants-2011_03 |