反応式
Cl[C:2]1[CH:16]=[CH:15][C:5]2[N:6]=[C:7]([NH:9][CH:10]3[CH2:14][CH2:13][NH:12][CH2:11]3)O[C:4]=2[CH:3]=1.[ClH:17].C([O:22][C:23]([N:25]1CCC(N)C1)=O)(C)(C)C>>[Cl:17][C:16]1[CH:15]=[C:5]2[C:4]([C:23](=[O:22])[NH:25][C:7]([NH:9][CH:10]3[CH2:14][CH2:13][NH:12][CH2:11]3)=[N:6]2)=[CH:3][CH:2]=1参加物
4
実験手順
In analogy to the procedure described for the synthesis of (6-Chloro-benzooxazol-2-yl)-pyrrolidin-3-yl-amine; hydrochloride (example 1, step 1) the title compound was prepared from 2,7-Dichloro-4(3H)-quinazoline (Bioorganic & Medicinal Chemistry 2003, 11, 2439-2444) and 3-Amino-pyrrolidine-1-carboxylic acid tert-butyl ester (commercially available) and subsequent cleavage of the tert-butyl oxy carbonyl protecting group under acidic conditions. (MH+) 265.1
出典と根拠
- ORDレコード
- ord-2a631bfdf66a481cb33645e9f27a24e9
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07897627B2
関連ノート
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