Hydrochloric Acid → (6-Chloro-benzooxazol-2-yl)-(R)-pyrrolidin-3-yl-amine, hydrochloride

HRID 598509

反応式

HRID 598509 の反応式
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]2[N:6]=[C:7]([NH:9][CH:10]3[CH2:14][CH2:13][NH:12][CH2:11]3)[O:8][C:4]=2[CH:3]=1.Cl.ClC1OC2C=C(Cl)C=CC=2N=1>>[ClH:1].[Cl:1][C:2]1[CH:16]=[CH:15][C:5]2[N:6]=[C:7]([NH:9][C@@H:10]3[CH2:14][CH2:13][NH:12][CH2:11]3)[O:8][C:4]=2[CH:3]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 771752,6-DichlorobenzoxazoleHCID 57748894(6-Chloro-benzooxazol-2-yl)-pyrrolidin-3-yl-amine

生成物 1

HCID 131728720(6-Chloro-benzooxazol-2-yl)-(R)-pyrrolidin-3-yl-amine, hydrochloride

実験手順

In analogy to the procedure described for the synthesis of (6-Chloro-benzooxazol-2-yl)-pyrrolidin-3-yl-amine; hydrochloride (example 1, step 1) the title compound was prepared from 2,6-dichloro-benzoxazole (commercially available) and R-3-amino-pyrrolidine-1-carboxylic acid tert-butyl ester (commercially available) and subsequent cleavage of the tert-butyl oxy carbonyl protecting group under acidic conditions. (MH+) 238.0.

出典と根拠

ORDレコード
ord-4269e0b778fa46ffacdf267cba5921d7
出典データセット
uspto-grants-2011_03
特許番号
US07897627B2

関連ノート

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