2-Chloro-7-(trifluoromethyl)quinoxaline → (5-Methyl-2-trifluoromethyl-phenyl)-[(R)-3-(7-trifluoromethyl-quinoxalin-2-ylamino)-pyrrolidin-1-yl]-methanone
反応式
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][C:6]([C:12]([F:15])([F:14])[F:13])=[CH:7][CH:8]=2)[N:3]=1.[NH2:16][C@@H:17]1[CH2:21][CH2:20][N:19]([C:22]([C:24]2[CH:29]=[C:28]([CH3:30])[CH:27]=[CH:26][C:25]=2[C:31]([F:34])([F:33])[F:32])=[O:23])[CH2:18]1>>[CH3:30][C:28]1[CH:27]=[CH:26][C:25]([C:31]([F:34])([F:32])[F:33])=[C:24]([C:22]([N:19]2[CH2:20][CH2:21][C@@H:17]([NH:16][C:2]3[CH:11]=[N:10][C:9]4[C:4](=[CH:5][C:6]([C:12]([F:15])([F:14])[F:13])=[CH:7][CH:8]=4)[N:3]=3)[CH2:18]2)=[O:23])[CH:29]=1参加物
3
実験手順
In analogy to the procedure described for example 200, the title compound was prepared from 2-chloro-7-trifluoromethyl-quinoxaline and ((R)-3-amino-pyrrolidin-1-yl)-(5-methyl-2-trifluoromethyl-phenyl)-methanone (intermediate 13). (M+H+) 469.2.
出典と根拠
- ORDレコード
- ord-473659bad37644f5869384eed047af24