Benzofuran → (RS)-2-(1-Benzofuran-2-yl-methanoyl)-4-methyl-piperazine-1-carboxylic acid tert-butyl ester

HRID 598563ノート

反応式

HRID 598563 の反応式
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH:9]1[C:15](=[O:20])N(OC)C)=[O:7])([CH3:4])[CH3:3].[O:21]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[CH:23]=[CH:22]1>>[C:2]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH:9]1[C:15]([C:22]1[O:21][C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[CH:23]=1)=[O:20])=[O:7])([CH3:1])([CH3:3])[CH3:4]

参加物

3

反応物 2

HCID 9223BenzofuranHCID 86625772(RS)-2-(methoxy-methyl-carbamoyl)4-methyl-piperazine-1-carboxylic acid dimethyl-ethyl ester

生成物 1

HCID 66968186(RS)-2-(1-Benzofuran-2-yl-methanoyl)-4-methyl-piperazine-1-carboxylic acid tert-butyl ester収率 52%

実験手順

The title compound (1.81 g, 52%) was prepared from (RS)-2-(methoxy-methyl-carbamoyl)-4-methyl-piperazine-1-carboxylic acid dimethyl-ethyl ester, D54 (2.9 g, 10.1 mmol) and benzofuran (0.74 g, 10.1 mol) using the method of Description 2.

出典と根拠

ORDレコード
ord-f6e7a548cb1f45b6ab5e8cefcf7a9380
出典データセット
uspto-grants-2011_03
特許番号
US07897618B2

反応ノート

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