2-Methyl-5-(4-fluorophenyl)thiazole-4-carbonyl chloride → HCID 23146349、化合物

反応式

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([CH3:13])=[N:10][C:9]=2[C:14](Cl)=[O:15])=[CH:4][CH:3]=1.[Cl:17][C:18]1[CH:19]=[CH:20][C:21]2[O:25][C:24]([CH2:26][CH:27]3[NH:32][CH2:31][CH2:30][N:29]([CH3:33])[CH2:28]3)=[CH:23][C:22]=2[CH:34]=1>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]2[O:25][C:24]([CH2:26][CH:27]3[CH2:28][N:29]([CH3:33])[CH2:30][CH2:31][N:32]3[C:14]([C:9]3[N:10]=[C:11]([CH3:13])[S:12][C:8]=3[C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)=[O:15])=[CH:23][C:22]=2[CH:34]=1

参加物

反応物 2

HCID 223241192-Methyl-5-(4-fluorophenyl)thiazole-4-carbonyl chloride

HCID 23146296HCID 23146296、化合物

生成物 1

HCID 23146349HCID 23146349、化合物

実験手順

The title compound (135 mg) was prepared from 5-(4-fluoro-phenyl)-2-methyl-thiazole-4-carbonyl chloride (211 mg) and 3-(5-Chloro-benzofuran-2-ylmethyl)-1-methyl-piperazine, D63 (200 mg) by a procedure similar to that described for Example 1.

出典と根拠

ORDレコード: ord-a4018229e0d34ec09065078ecc7ab2fe
出典データセット: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07897618B2

反応ノート

読み込み中…