化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 1-(4-Fluorophenoxy)-2-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 4-Fluorophenol | HCID 9732 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | 2-(4-Fluorophenoxy)aniline | HCID 6485399 | — |
| 生成物 | 1-(4-Fluorophenoxy)-2-nitrobenzene | HCID 961127 | 75% |
| 生成物 | N-[2-(4-Fluorophenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732937 | 72% |
反応手順
2-(4-Fluorophenoxy)-1-nitrobenzene (0.87 g, 75%) was prepared from 4-fluorophenol (0.62 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(4-fluorophenoxy)aniline (0.51 g, 68%) following general procedure B. N-[2-(4-Fluorophenoxy)phenyl]-N′-(thiazol-2-yl)urea (118 mg, 72%) was prepared from 2-(4-fluorophenoxy)aniline (102 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07897628B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-21234f5251164b3a882b72b03e46bef1 |
| 出典メモ | uspto-grants-2011_03 |