化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 1-Nitro-2-[2-(trifluoromethyl)phenoxy]benzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 2-Trifluoromethylphenol | HCID 67958 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | 2-[2-(Trifluoromethyl)phenoxy]aniline | HCID 20362101 | — |
| 生成物 | 1-Nitro-2-[2-(trifluoromethyl)phenoxy]benzene | HCID 20163311 | 65% |
| 生成物 | n-[2-(2-Trifluoromethylphenoxy)phenyl]-n'-(thiazol-2-yl)urea | HCID 59733085 | 61% |
反応手順
2-[2-(Trifluoromethyl)phenoxy]-1-nitrobenzene (0.92 g, 65%) was prepared from 2-hydroxybenzotrifluoride (0.89 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-[2-(trifluoromethyl)phenoxy]aniline (0.56 g, 68%) following general procedure B. N-[2-(2-Trifluoromethylphenoxy)phenyl]-N′-(thiazol-2-yl)urea (115 mg, 61%) was prepared from 2-[2-(trifluoromethyl)phenoxy]aniline (127 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07897628B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-d51d9eecfabe468baf5c14b90328466f |
| 出典メモ | uspto-grants-2011_03 |