化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 5-Fluoro-2-(2-trifluromethylphenoxy)-1-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| 反応物 | 2-Trifluoromethylphenol | HCID 67958 | — |
| 反応物 | 2-(2-Trifluoromethylphenoxy)-5-fluoroaniline | HCID 28412097 | — |
| 生成物 | n-[5-Fluoro-2-(2-trifluoromethylphenoxy)phenyl]-n'-(thiazol-2-yl)urea | HCID 59732964 | 74% |
| 生成物 | 5-Fluoro-2-(2-trifluromethylphenoxy)-1-nitrobenzene | HCID 66998992 | 78% |
反応手順
5-Fluoro-2-(2-trifluoromethylphenoxy)-1-nitrobenzene (1.17 g, 78%) was prepared from 2-hydroxybenzotrifluoride (0.89 g, 5.5 mmol) and 2,5-difluoro-1-nitrobenzene (0.8 g, 5.0 mmol) following the general procedure A. This compound was reduced to 5-fluoro-2-(2-trifluoromethylphenoxy)-aniline (0.65 g, 62%) following the general procedure B. N-[5-Fluoro-2-(2-trifluoromethylphenoxy)phenyl]-N′-(thiazol-2-yl)urea (146 mg, 74%) was prepared from 2-(2-trifluoromethylphenoxy)-5-fluoroaniline (135 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07897628B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-70714b9f684b4631a985f8ea0bd065ab |
| 出典メモ | uspto-grants-2011_03 |