化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 2-(2-Chloro-4-fluorophenylsulfanyl)nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | 2-Chloro-4-fluorothiophenol | HCID 519446 | — |
| 反応物 | 2-(2-Chloro-4-fluorophenylsulfanyl)aniline | HCID 66998238 | — |
| 生成物 | N-[2-(2-Chloro-4-fluorophenylsulfanyl)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732752 | 76% |
| 生成物 | 2-(2-Chloro-4-fluorophenylsulfanyl)nitrobenzene | HCID 66998960 | 80% |
反応手順
2-(2-Chloro-4-fluorophenylsulfanyl)nitrobenzene (1.13 g, 80%) was prepared from 2-chloro-4-fluorothiophenol (0.89 g, 5.5 mmol) and 2-fluoronitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(2-chloro-4-fluorophenylsulfanyl)aniline (0.76 g, 75%) following the general procedure B. N-[2-(2-Chloro-4-fluorophenylsulfanyl)phenyl]-N′-(thiazol-2-yl)urea (144 mg, 76%) was prepared from 2-(2-chloro-4-fluorophenylsulfanyl)aniline (126 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07897628B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-00e7ab67df424e3981dbb6018d64abce |
| 出典メモ | uspto-grants-2011_03 |