化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 2-(Allyloxy)-4-methyl-1-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | Allyl Alcohol | HCID 7858 | — |
| 反応物 | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| 反応物 | 4-Methyl-2-(2-methylpropoxy)aniline | HCID 24693559 | — |
| 反応物 | 4-Methyl-2-[(prop-2-en-1-yl)oxy]aniline | HCID 39235899 | — |
| 生成物 | 2-(Allyloxy)-4-methyl-1-nitrobenzene | HCID 13575666 | 70% |
| 生成物 | 1-(2-Allyloxy-4-methyl-phenyl)-3-thiazol-2-yl-urea | HCID 59732961 | 68% |
反応手順
3-Allyloxy-4-nitrotoluene (0.67 g, 70%) was prepared from allyl alcohol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 4-methyl-2-(allyloxy)aniline (0.40 g, 70%) following general procedure B. 1-(2-Allyloxy-4-methyl-phenyl)-3-thiazol-2-yl-urea (196 mg, 68%) was prepared from 4-methyl-2-(2-methylpropoxy)aniline (163 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07897628B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-5fa49927fd1c43df9ff0c76168da747c |
| 出典メモ | uspto-grants-2011_03 |