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HRID 599146作成日：2026年10月27日

Triethylamine → N-{5-[2-(4-Fluoro-phenylamino)-pyrimidin-4-yl]-4-methyl-thiazol-2-yl}-methanesulfonamide

https://huagongshe.com/reaction/599146

反応式

関与物質

役割名称HCID仕込み量
反応物TriethylamineHCID 8471—
反応物Methanesulfonyl chlorideHCID 31297—
反応物[4-(2-Amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(4-fluoro-phenyl)-amineHCID 9857535—
溶媒DimethylformamideHCID 6228—
生成物N-{5-[2-(4-Fluoro-phenylamino)-pyrimidin-4-yl]-4-methyl-thiazol-2-yl}-methanesulfonamideHCID 10091115—

反応手順

This compound was prepared from [4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(4-fluoro-phenyl)-amine by treatment with methylsulfonyl chloride and Et3N in DMF. Gray solid; 1H-NMR (DMSO-d6) δ: 3.31 (s, 3H, CH3), 3.63 (s, 3H, CH3), 7.32 (m, 1H, pyrimidinyl-H), 7.42 (m, 2H, Ph-H), 8.11 (m, 2H, Ph-H), 8.63 (d, 1H, J=5.0 Hz, pyrimidinyl-H).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07897605B2
出典データセットuspto-grants-2011_03
ORD IDord-2c58e1584f5c46ad9136c96e32dadd3e
出典メモuspto-grants-2011_03