Lithium Hydroxide → HCID 118366218、化合物

関与物質

役割	名称	HCID	仕込み量
反応物	Lithium Hydroxide	HCID 3939	—
反応物	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
反応物	Methyl 3-(aminomethyl)-4-fluorobenzoate hydrochloride	HCID 75422100	—
反応物	(R)-2-(3-(2-ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic acid	HCID 118366221	—
生成物	HCID 118366218	HCID 118366218	—

反応手順

(R)-3-((2-(3-(2-ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxamido)methyl)-4-fluorobenzoic acid was prepared from (R)-2-(3-(2-ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic acid and methyl 3-(aminomethyl)-4-fluorobenzoate hydrochloride using Amidation Method 1 (HATU) and Ester Hydrolysis Method 1 (LiOH). 1H NMR (300 MHz, DMSO-d6) δ 8.92 (m, 1H), 8.78 (s, 2H), 7.91 (d, 1H), 7.85 (m, 1H), 7.19 (dd, 1H), 7.05 (d, 1H), 6.90 (m, 3H), 4.51 (d, 2H), 4.32 (m, 1H), 4.20 (d, 1H), 3.90 (m, 5H), 2.05 (m, 1H), 1.83 (m, 2H), 1.52 (m, 1H), 1.21 (t, 3H). MS (ES+) 495.0 (M+H).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09440949B2
出典データセット	uspto-grants-2016_09
ORD ID	ord-5be4c619c45f49a9863dc1c84d2c0c52
出典メモ	uspto-grants-2016_09