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HRID 599195作成日：2026年10月27日

Ammonia → Benzo[b]thiophene-3-carboxylic acid (4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride

https://huagongshe.com/reaction/599195

反応式

関与物質

役割名称HCID仕込み量
反応物AmmoniaHCID 222—
反応物Benzo(b)thiophene-3-carboxylic acidHCID 601280—
反応物1-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochlorideHCID 67152122—
生成物Benzo[b]thiophene-3-carboxylic acid (4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochlorideHCID 67152137—

反応手順

Prepared from (4r)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 1-benzothiophene-3-carboxylic acid (Maybridge) according to methods A and C; yield 60 mg, 0.17 mmol (56%): 1H NMR (300 MHz, methanol-d4) δ 2.10-2.30 (m, 5H), 2.48 (s, 2H), 3.50 (d, J=13 Hz, 2H), 3.56 (s, 2H), 3.83 (d, J=13 Hz, 2H), 4.33 (s, 1H), 7.36-7.49 (m, 2H), 7.91-7.96 (m, 1H), 8.28-8.34 (m, 2H); MS (DCI/NH3) m/z 313 (M+H)+; Anal. C18H20N2OS.HCl.0.17H2O: C, H, N.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07897766B2
出典データセットuspto-grants-2011_03
ORD IDord-393f60447c354868addbeb95f0cd1b64
出典メモuspto-grants-2011_03