Ammonia → 1H-Indole-6-carboxylic acid(4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride

HRID 599199

反応式

HRID 599199 の反応式
[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH2:12])[CH2:3]1)[CH2:9]2.[NH:13]1[C:21]2[C:16](=[CH:17][CH:18]=[C:19]([C:22](O)=[O:23])[CH:20]=2)[CH:15]=[CH:14]1.N>>[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH:12][C:22]([C:19]3[CH:20]=[C:21]4[C:16]([CH:15]=[CH:14][NH:13]4)=[CH:17][CH:18]=3)=[O:23])[CH2:3]1)[CH2:9]2

参加物

4

反応物 3

HCID 222AmmoniaHCID 5952301H-indole-6-carboxylic acidHCID 671521221-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride

生成物 1

HCID 671522071H-Indole-6-carboxylic acid(4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride

実験手順

Prepared from (4r)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and indole-6-carboxylic acid (Lancaster) according to methods A and C; yield 59 mg, 0.17 mmol (48%): 1H NMR (300 MHz, methanol-d4) δ 2.12-2.30 (m, 6H), 2.49 (s, 2H), 3.49 (d, J=12 Hz, 2H), 3.56 (s, 2H), 3.85 (d, J=13 Hz, 2H), 4.29 (s, 1H), 7.41 (d, J=3 Hz, 1H), 7.55 (dd, J=8, 2 Hz, 1H), 7.62 (d, J=12 Hz, 1H), 7.94-8.04 (m, 1H), 8.22 (d, J=5 Hz, 1H); MS (DCI/NH3) m/z 296 (M+H)+; Anal. C18H21N3O.HCl.0.75H2O: C, H, N.

出典と根拠

ORDレコード
ord-5251459946f44208ad6f3a9bc44dfb25
出典データセット
uspto-grants-2011_03
特許番号
US07897766B2

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