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Ammonia → 5-Phenylthiophene-2-carboxylic acid (4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 5-Phenyl-2-Thiophenecarboxylic Acid | HCID 736494 | — |
| 反応物 | 1-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride | HCID 67152122 | — |
| 生成物 | 5-Phenylthiophene-2-carboxylic acid (4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride | HCID 67152107 | — |
反応手順
Prepared from (4r)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 5-phenylthiophene-2-carboxylic acid (Maybridge) according to methods A and C; yield 62 mg, 0.17 mmol (53%): 1H NMR (300 MHz, methanol-d4) δ 2.08-2.27 (m, 5H), 2.47 (s, 2H), 3.48 (d, J=13 Hz, 2H), 3.55 (s, 2H), 3.81 (d, J=13 Hz, 2H), 4.25 (t, J=3 Hz, 1H), 7.32-7.47 (m, 4H), 7.65-7.71 (m, 2H), 7.83 (d, J=4 Hz, 1H); MS (DCI/NH3) m/z 339 (M+H)+; Anal. C20H22N2OS.HCl: C, H, N.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07897766B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-4816501204ef4f17857ec644e1477f12 |
| 出典メモ | uspto-grants-2011_03 |