Ammonia → 2,2'-Bithiophene-5-carboxylic acid (4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride

関与物質

反応手順

Prepared from (4r)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 2,2′-bithiophene-5-carboxylic acid (Acros) according to methods A and C; yield 142 mg, 0.37 mmol (93%): 1H NMR (300 MHz, methanol-d4) δ 2.06-2.27 (m, 5H), 2.46 (s, 2H), 3.49 (d, J=13 Hz, 2H), 3.55 (s, 2H), 3.82 (d, J=13 Hz, 2H), 4.24 (s, 1H), 7.08 (dd, J=5, 4 Hz, 1H), 7.24 (d, J=4 Hz, 1H), 7.35 (dd, J=4, 1 Hz, 1H), 7.43 (dd, J=5, 1 Hz, 1H), 7.79 (d, J=4 Hz, 1H); MS (DCI/NH3) m/z 345 (M+H)+; Anal. C18H20N2OS2.HCl: C, H, N.

情報源と証拠