化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 5-(3-Trifluoromethylphenyl)-furan-2-carboxylic acid(4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 5-(3-(Trifluoromethyl)phenyl)-2-furoic acid | HCID 688281 | — |
| 反応物 | 1-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride | HCID 67152122 | — |
| 生成物 | 5-(3-Trifluoromethylphenyl)-furan-2-carboxylic acid(4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride | HCID 67152105 | — |
反応手順
Prepared from (4s)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 5-[3-(trifluoromethyl)phenyl]-2-furoic acid (Aldrich) according to methods A and C; yield 44 mg, 0.11 mmol (51%): 1H NMR (300 MHz, methanol-d4) δ 1.99 (d, J=14 Hz, 2H), 2.22 (s, 1H), 2.34 (d, J=14 Hz, 2H), 2.52 (s, 2H), 3.58 (s, 2H), 3.69 (s, 4H), 4.43 (s, 1H), 7.12 (d, J=4 Hz, 1H), 7.34 (d, J=4 Hz, 1H), 7.64-7.69 (m, 2H), 8.11-8.17 (m, 1H), 8.24 (s, 1H); MS (DCI/NH3) m/z 391 (M+H)+; Anal. C21H21F3N2O2.HCl: C, H, N.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07897766B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-6c0c400b061e4b5db41b728b6ff1417d |
| 出典メモ | uspto-grants-2011_03 |