Hydrochloric Acid → 1-[(3-Pyridin-3-yl-8-azabicyclo[3.2.1]oct-8-yl)carbonyl]-1,2,3,4-tetrahydroquinoline hydrochloride

HRID 599350ノート

反応式

HRID 599350 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]2[CH2:13][CH:12]3[N:14]([C:15]([N:17]4[C:26]5[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=5)[CH2:20][CH2:19][CH2:18]4)=[O:16])[CH:9]([CH2:10][CH2:11]3)[CH2:8]2)[CH:2]=1.[ClH:27]>ClCCl.O1CCOCC1>[ClH:27].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]2[CH2:13][CH:12]3[N:14]([C:15]([N:17]4[C:26]5[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=5)[CH2:20][CH2:19][CH2:18]4)=[O:16])[CH:9]([CH2:10][CH2:11]3)[CH2:8]2)[CH:2]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 249575581-[(3-Pyridin-3-yl-8-azabicyclo[3.2.1]oct-8-yl)carbonyl]-1,2,3,4-tetrahydroquinoline

生成物 1

HCID 249575571-[(3-Pyridin-3-yl-8-azabicyclo[3.2.1]oct-8-yl)carbonyl]-1,2,3,4-tetrahydroquinoline hydrochloride

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

0.146 g of 1-[(3-pyridin-3-yl-8-azabicyclo[3.2.1]oct-8-yl)carbonyl]-1,2,3,4-tetrahydroquinoline is dissolved in 6 ml of dichloromethane and 4.2 ml of a 4N solution of hydrochloric acid in dioxane are added. After evaporation, the residue is taken up in ethyl acetate. The precipitate is filtered off and then dried under vacuum. 0.122 g of 1-[(3-pyridin-3-yl-8-azabicyclo[3.2.1]oct-8-yl)carbonyl]-1,2,3,4-tetrahydroquinoline hydrochloride is obtained.

後処理

  1. customAfter evaporation
  2. filtrationThe precipitate is filtered off
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-a8684fedbf374b13a932cb7a737047d2
出典データセット
uspto-grants-2011_03
特許番号
US07897773B2

反応ノート

読み込み中…