Hydrochloric Acid → 3-Pyridin-4-yl-8-azabicyclo[3.2.1]octane dihydrochloride
反応式
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]2[CH2:13][CH:12]3[N:14](C(OC(C)(C)C)=O)[CH:9]([CH2:10][CH2:11]3)[CH2:8]2)=[CH:3][CH:2]=1.[ClH:22]>O1CCOCC1>[ClH:22].[ClH:22].[N:1]1[CH:6]=[CH:5][C:4]([CH:7]2[CH2:13][CH:12]3[NH:14][CH:9]([CH2:10][CH2:11]3)[CH2:8]2)=[CH:3][CH:2]=1参加物
4
実験手順
2.76 g of tert-butyl 3-pyridin-4-yl-8-azabicyclo[3.2.1]octane-8-carboxylate and 4 ml of a 4N solution of hydrochloric acid in dioxane are placed in a 10 ml round-bottomed flask. The reaction mixture is stirred for one and a half hours. The dioxane is evaporated off and 0.341 g of 3-pyridin-4-yl-8-azabicyclo[3.2.1]octane dihydrochloride is obtained.
後処理
- customThe dioxane is evaporated off
出典と根拠
- ORDレコード
- ord-e3fa632933b54cd9a0623c90de3a695f
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07897773B2
反応ノート
読み込み中…