関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Chlorosuccinimide | HCID 31398 | — |
| 反応物 | 4-Amino-3-fluorobenzonitrile | HCID 2756431 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 4-Amino-3-chloro-5-fluorobenzonitrile | HCID 68039995 | — |
反応手順
A mixture of 4-amino-3-fluorobenzonitrile (184 mmol) and NCS (276 mmol) in AcOH (300 mL) was stirred at 70° C. for approximately 16 h. The mixture was concentrated. H2O was added to the residue and the solid product was filtered off and washed (sat. NaHCO3 and H2O). To eliminate H2O, THF was added and removed under reduced pressure to yield the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09440929B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-306095c73a9a4bfabc97bcd9d3ba38ab |
|---|
| 出典メモ | uspto-grants-2016_09 |
|---|
