Sulfuric Acid → HCID 68322517、化合物

HRID 59942

反応式

HRID 59942 の反応式
OS(O)(=O)=O.N[C:7]1[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][C:8]=1[CH2:15][CH3:16].N([O-])=[O:18].[Na+]>O>[CH2:15]([C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][C:7]=1[OH:18])[C:11]#[N:12])[CH3:16]

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 27353304-Amino-3-ethylbenzonitrileHCID 23668193Sodium Nitrite

生成物 1

HCID 68322517HCID 68322517、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
100 °C

実験手順

Concentrated H2SO4 (3.4 mL) was added dropwise to a solution of 4-amino-3-ethylbenzonitrile (6.84 mmol) in H2O (12 mL) at 0° C. A solution of NaNO2 (7.52 mmol) in H2O (5 mL) was added dropwise at 0° C. to the resulting mixture. The reaction was stirred at 0° C. for 30 min and at 100° C. for 2 h. The mixture was cooled to room temperature and extracted with EtOAc. The organic layer was washed (H2O), dried and concentrated to yield the desired product.

後処理

  1. temperatureThe mixture was cooled to room temperature
  2. extractionextracted with EtOAc
  3. washThe organic layer was washed (H2O)
  4. customdried
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-33b4df3f08864a06bc6dd8ba3ccfe5e1
出典データセット
uspto-grants-2016_09
特許番号
US09440929B2

関連ノート

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