Urea → 4-Oxo-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester
反応式
[O:1]=[C:2]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH2:3][C:4]([O:6][CH3:7])=[O:5].[CH:13](OCC)(OCC)OCC.N[C:24]([NH2:26])=O>C1(C)C(C)=CC=CC=1>[O:1]=[C:2]1[C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:24][NH:26][CH:13]=[C:3]1[C:4]([O:6][CH3:7])=[O:5]参加物
5
実験手順
A mixture of dimethyl 3-oxopentanedioate (12 g, 69 mmol), CH(OEt)3 (15.1 g, 100 mmol) and urea (6 g, 100 mmol) in xylene (25 mL) was heated to reflux for 3 hours. The mixture was cooled to room temperature and the precipitate was filtered, washed with xylene and DCM to afford the title compound as white solid (yield 82.3%).
後処理
- temperaturewas heated
- temperatureto reflux for 3 hours
- filtrationthe precipitate was filtered
- washwashed with xylene and DCM
出典と根拠
- ORDレコード
- ord-b7e52f2fac1f4af8908e41e0da758d72
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09440968B2
反応ノート
読み込み中…